Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and <i>Ex Vivo</i> Particle–Immune Cell Interactions in Human Blood
نویسندگان
چکیده
Poly(ethylene glycol) (PEG) is widely used in particle assembly to impart biocompatibility and stealth-like properties vivo for diverse biomedical applications. Previous studies have examined the effect of PEG molecular weight coating density on biological fate various particles; however, there are few that detail fundamental role architecture engineering bio–nano interactions. Herein, we engineered particles using a mesoporous silica (MS) templating method investigated how building block impacted physicochemical (e.g., surface chemistry mechanical characteristics) subsequently modulated particle–immune cell interactions human blood. Varying from 3-arm 4-arm, 6-arm, 8-arm generated with denser, stiffer structure, increasing elastic modulus 1.5 14.9 kPa, inducing an level immune association (from 15% 45% 8-arm) monocytes. In contrast, precursor template intact (MS@PEG) were generally displayed higher levels but showed opposite trend?immune decreased arm numbers. Proteomics analysis demonstrated biomolecular corona formed minimally influenced interactions, whereas MS@PEG particle–cell correlated composition was abundant histidine-rich glycoproteins. Our work highlights design stealth PEG-based particles, thus providing link between synthetic nature their behavior
منابع مشابه
Surface Adsorption of Polyethylene Glycol and Polyvinyl Alcohol with Variable Molecular Weights on Zinc Oxide Nanoparticles
متن کامل
critical period effects in foreign language learning:the influence of maturational state on the acquisition of reading,writing, and grammar in english as a foreign language
since the 1960s the age effects on learning both first and second language have been explored by many linguists and applied linguists (e.g lennerberg, 1967; schachter, 1996; long, 1990) and the existence of critical period for language acquisition was found to be a common ground of all these studies. in spite of some common findings, some issues about the impacts of age on acquiring a second or...
15 صفحه اولCell fusion and intramembrane particle distribution in polyethylene glycol-resistant cells
The distribution of intramembrane particles (IMP) as revealed by freeze-fracture electron microscopy has been analyzed following treatment of mouse L cells and fusion-deficient L cell derivatives with several concentrations of polyethylene glycol (PEG). In cell cultures treated with concentrations of PEG below the critical level for fusion, no aggregation of IMP was observed. When confluent cul...
متن کاملCell Fusion and Intramembrane Particle in Polyethylene Glycol-resistant Cells Distribution
The distribution of intramembrane particles (IMP) as revealed by freeze-fracture electron microscopy has been analyzed following treatment of mouse L cells and fusiondeficient L cell derivatives with several concentrations of polyethylene glycol (PEG). In cell cultures treated with concentrations of PEG below the critical level for fusion, no aggregation of IMP was observed. When confluent cult...
متن کاملStability of Trinitroglycerin in Polyethylene Glycol 400
In this study, the stability of trinitroglycerin (TNG) in polyethylene (PEG) 400 was investigated according to Arrhenius approach. The reaction rate constant (k) for the thermal disintegration of TNG in PEG 400 at various temperatures was counted based on the percents of remaining TNG at different intervals of time at a specific temperature. The results showed that “k” at 40, 50, 60, 70, 8...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Nano
سال: 2021
ISSN: ['1936-0851', '1936-086X']
DOI: https://doi.org/10.1021/acsnano.1c01642